DETERMINATION OF ASPIRIN CONTENT IN PHARMACEUTICAL TABLETS BY CONDUCTOMETRIC TITRATION

Authors

  • Enes Dauti Chemistry Study Program, Faculty of Natural Sciences and Mathematics, University of Tetova, Street Ilindeni Street, No. Nr., 1200 Tetova, Republic of North Macedonia
  • Arbana Durmishi Chemistry Study Program, Faculty of Natural Sciences and Mathematics, University of Tetova, Street Ilindeni Street, No. Nr., 1200 Tetova, Republic of North Macedonia
  • Hamdije Memedi Chemistry Study Program, Faculty of Natural Sciences and Mathematics, University of Tetova, Street Ilindeni Street, No. Nr., 1200 Tetova, Republic of North Macedonia
  • Bujar H. Durmishi Chemistry Study Program, Faculty of Natural Sciences and Mathematics, University of Tetova, Street Ilindeni Street, No. Nr., 1200 Tetova, Republic of North Macedonia
  • Agim Shabani Chemistry Study Program, Faculty of Natural Sciences and Mathematics, University of Tetova, Street Ilindeni Street, No. Nr., 1200 Tetova, Republic of North Macedonia

DOI:

https://doi.org/10.58885/ijcms.v10i1.23.ed

Keywords:

Aspirin, Conductometric Titration, Acetylsalicylic Acid, Pharmaceutical Analysis, Quantitative Determination.

Abstract

Objective: The aim of this paper is to determine the quantitative content of acetylsalicylic acid (aspirin) in pharmaceutical tablets using conductometric titration as a simple, accurate, and efficient alternative to traditional analytical methods.

Methodology: The methodology involved dissolving the tablet sample in distilled water and titrating it with a standard sodium hydroxide (NaOH) solution, while monitoring the changes in conductivity during the titration process. The equivalence point was identified from the graph of conductivity versus titrant volume.

Results and Discussion: The results and discussion demonstrated a strong correlation between the labeled amount of aspirin in the pharmaceutical formulation and the experimentally determined value. The method showed high reproducibility, with low standard deviations and satisfactory precision.

Conclusions: The conclusion of this research is that conductometric titration is a simple, fast, and reliable method for the quantitative analysis of aspirin in pharmaceutical products, and it is suitable for use in both pharmaceutical quality control and educational laboratory settings.

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Published

2025-06-23 — Updated on 2025-06-23

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How to Cite

Enes Dauti, Arbana Durmishi, Hamdije Memedi, Bujar H. Durmishi, & Agim Shabani. (2025). DETERMINATION OF ASPIRIN CONTENT IN PHARMACEUTICAL TABLETS BY CONDUCTOMETRIC TITRATION. International Journal of Chemistry & Materials Sciences (IJCMS), 10(1), 23–34. https://doi.org/10.58885/ijcms.v10i1.23.ed

Issue

Vol. 10 No. 1 (2025): International Journal of Chemistry & Material Sciences (IJCMS)

Section

ORIGINAL RESEARCH

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